ELISpot Human IFN-γ Kit + HHV-6 Peptide Pool
Cat #:
3066

ELISpot Human IFN-γ Kit + HHV-6 Peptide Pool

£ 280.00

Shipped within 2-3 days
Product Details
Application: ELISpot
Analyte: IFN-γ
Reactivity: Human
Storage: Store plates and reagents between 2 and 8°C. Peptide pool vial must be stored at -20 °C or below.
Shelf Life: 12 months
Peptide Pools​: ImmuneSelect HHV-6 (42 peptides covering immunodominant MHC-I and MHC-II epitopes)
Plates​: ELISpot plate precoated with IFN-γ capture antibody
Detection mAb​​: Biotinylated recombinant IFN-γ antibody
Enzyme conjugate​: Streptavidin-ALP (Alkaline Phosphatase)
Substrate: BCIP/NBT Ready-to-use solution
Blocking agent: Bovine Serum Albumin (BSA)
Human Herpesvirus 6 (HHV-6) is a common herpesvirus that infects nearly all humans by the age of three. It is the causative agent of roseola infantum (exanthem subitum) and has been associated with various clinical conditions, including febrile seizures, encephalitis, and bone marrow suppression in immunocompromised individuals. There is also evidence to suggest that the virus may be linked to reproductive disorders such as infertility. HHV-6 exists in two variants, HHV-6A and HHV-6B, with HHV-6B being more commonly linked to clinical disease. Accurate diagnosis of HHV-6 is crucial for initiating timely antiviral therapy, particularly in severe cases and in immunocompromised patients. Early detection and intervention is critical to reduce morbidity and mortality associated with HHV-6 reactivation and disease. The immune response to HHV-6, particularly T cell mediated immunity, is crucial for controlling the infection and preventing disease reactivation. ELISpot assays can be used to measure HHV-6-specific T cell response by detecting the cytokine production in response to peptide derived from HHV-6 antigens. Research has shown that robust HHV-6-specific T cell responses are associated with better clinical outcomes for transplant recipients, underscoring the importance of immune monitoring in HHV-6 infection management.

The HHV-6 Human IFN-γ Enzyme-Linked ImmunoSpot (ELISpot) kit is a highly sensitive method used to detect and quantify individual cells that secrete IFN-γ after stimulation with the ImmuneSelect HHV-6 Peptide Pool. This assay is utilized in immunology to monitor cellular immune responses at the single-cell level and reliably detects and measures human IFN-γ secretion by HHV-6 stimulated effector cells.

 

Description

Human Herpesvirus 6 (HHV-6) is a common herpesvirus that infects nearly all humans by the age of three. It is the causative agent of roseola infantum (exanthem subitum) and has been associated with various clinical conditions, including febrile seizures, encephalitis, and bone marrow suppression in immunocompromised individuals. There is also evidence to suggest that the virus may be linked to reproductive disorders such as infertility. HHV-6 exists in two variants, HHV-6A and HHV-6B, with HHV-6B being more commonly linked to clinical disease. Accurate diagnosis of HHV-6 is crucial for initiating timely antiviral therapy, particularly in severe cases and in immunocompromised patients. Early detection and intervention is critical to reduce morbidity and mortality associated with HHV-6 reactivation and disease. The immune response to HHV-6, particularly T cell mediated immunity, is crucial for controlling the infection and preventing disease reactivation. ELISpot assays can be used to measure HHV-6-specific T cell response by detecting the cytokine production in response to peptide derived from HHV-6 antigens. Research has shown that robust HHV-6-specific T cell responses are associated with better clinical outcomes for transplant recipients, underscoring the importance of immune monitoring in HHV-6 infection management.

Application

The HHV-6 Human IFN-γ Enzyme-Linked ImmunoSpot (ELISpot) kit is a highly sensitive method used to detect and quantify individual cells that secrete IFN-γ after stimulation with the ImmuneSelect HHV-6 Peptide Pool. This assay is utilized in immunology to monitor cellular immune responses at the single-cell level and reliably detects and measures human IFN-γ secretion by HHV-6 stimulated effector cells.

 

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Frequently Asked Questions

Virax Biolabs develops and provides immunology-profiling solutions, with a focus on T cell diagnostics and immune monitoring. Their offerings include research-use products (e.g., peptide pools, ELISpot/FluoroSpot kits, high-affinity antibodies) as well as custom immunology services (such as recombinant antibody engineering, peptide synthesis and protein sequencing).

Virax Biolabs offers a comprehensive range of products to support immunology research and diagnostic development. Their primary product categories include pathogen-specific peptide pools that enable T cell stimulation and immune-response analysis, ELISpot and FluoroSpot kits designed for measuring cytokine secretion and other immune markers, and high-affinity antibodies suitable for use in assays such as ELISA, flow cytometry, and ELISpot. Together, these products provide researchers with precise tools for profiling immune responses in various disease and vaccine studies.

Virax Biolabs provides a range of custom immunology services to meet the diverse needs of academic and industry clients. These services include recombinant antibody engineering, which involves antigen discovery, sequencing, formatting, and bio-conjugation. They also offer custom peptide synthesis and protein sequencing using advanced mass spectrometry, as well as laboratory services that support ELISA, ELISpot, FluoroSpot, and flow cytometry assays. These custom services are designed to help researchers accelerate discovery and optimize immune-response studies.

Virax Biolabs primarily serves researchers and organizations engaged in immunology, infectious disease, and vaccine development. Their customer base includes academic laboratories, biotechnology companies, and pharmaceutical firms that require high-quality immune-profiling tools and diagnostic support. By providing both off-the-shelf research products and tailored immunology services, Virax Biolabs enables scientists to investigate T cell activity, evaluate vaccine efficacy, and develop new diagnostic platforms.

Virax Biolabs’ headquarters is located at BioCity Glasgow, Bo’Ness Road, Newhouse, Lanarkshire, ML1 5UH, United Kingdom. Inquiries can be made through the “Contact” section of their website at viraxbiolabs.com.

Many of Virax Biolabs’ products, including peptide pools and ELISpot kits, are intended for research use in immune-profiling and in-vitro studies. However, the company is also developing in-vitro diagnostic (IVD) platforms and T cell diagnostics for applications such as chronic inflammation and immune exhaustion. The intended use and regulatory status vary by product, so customers should refer to the specific product details or contact the company directly for clarification.

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